|
rs1057518923
|
|
GC |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs112417755
|
|
C |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs138924661
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs373909351
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs398123538
|
|
C |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs777476179
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings indicate that the MTHFR 677C>T polymorphism may be associated with an elevated risk for CVD in ESRD patients, especially among Asians.
|
25050994 |
2014 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The evidence accumulated suggested that 4b/a and G894T polymorphisms in the eNOS gene were associated with ESRD susceptibility, indicating that 4a and T allele carriers might become significant genetic molecular markers for the onset of ESRD in overall populations.
|
24673298 |
2014 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
GG genotype of the Glu298Asp variant slowed the ESRD progression in ADPKD, while a allele carriers of the 4b/a variant increased the risk of ESRD.
|
24995932 |
2014 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, a link between eNOS Glu298Asp gene polymorphism and ESRD risk was not found in Caucasians and Brazil population.
|
23464568 |
2013 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Since the Glu298Asp variant in the eNOS gene alters caveolar localization of the corresponding enzyme, we tested the interaction between this variant and the rs4730751 polymorphism of the caveolin-1 (CAV-1) gene as related to arterial remodeling in end-stage renal disease (ESRD) patients.
|
21976276 |
2012 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Impact of nitric oxide synthase Glu298Asp polymorphism on the development of end-stage renal disease in type 2 diabetic Egyptian patients.
|
21854353 |
2011 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The carrier of FVL, TT genotype of C677T, and CC genotype of A1298C polymorphisms may act as risk factors for ESRD.
|
19520684 |
2010 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The frequency of MTHFR 1298CC genotype was significantly higher in ESRD patients than in controls (21.4% vs. 2.9%); the frequency of the MTHFR C677T genotypes did not differ between groups (26.1% vs. 17.4%).
|
17899317 |
2008 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results suggested that the Glu298Asp polymorphism of NOS3 gene is associated with the onset age of ESRD.
|
18815450 |
2008 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
It appears that Glu298Asp may be a predisposing factor in DM-derived and HT-derived ESRD.
|
18793530 |
2008 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found no evidence for survival bias due to C677T genotype in the ESRD cohort, or bias due to genetically determined accelerated progression to novel microalbuminuria in the controls.
|
17005529 |
2007 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We tested the relationship between carotid intima-media thickness (IMT) and three endothelial NO synthase (eNOS) polymorphisms (G894T, T-786C, and 27-bp repeat in intron 4) in an ethnically and geographically homogeneous group of 147 patients with ESRD.
|
17586410 |
2007 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this case-control, cross-sectional study the frequency of the MTHFR 677C --> T and the 1298A --> C polymorphism was compared between patients with hypertension-related chronic renal failure (n = 90), patients with essential hypertension without kidney injury (n = 90), and healthy individuals (n = 90) who were matched for age and gender.
|
16280279 |
2005 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Atherosclerosis and the Glu298Asp polymorphism of the eNOS gene in white patients with end-stage renal disease.
|
16364824 |
2005 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The GLU298ASP variant of nitric oxide synthase interacts with asymmetric dimethyl arginine in determining cardiovascular mortality in patients with end-stage renal disease.
|
16148605 |
2005 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The endothelial nitric oxide synthase Glu298Asp and Asp29Asp genotypes were significantly more frequent in rapid progressors (9.6% (7/73) Asp/Asp, 39.7% (29/73) Asp/Glu, 50.7% (37/73) Glu/Glu) and in ADPKD group with ESRF between 40-63 years (11.3% (16/142) Asp/Asp, 41.5% (59/142) Asp/Glu, 47.2% (67/142) Glu/Glu) in comparison with slow progressors (8.8% (8/91) Asp/Asp, 24.2% (22/91) Asp/Glu, 67.0% (61/91) Glu/Glu) and with control group (8% Asp/Asp, 32% Asp/Glu, 60% Glu/Glu) (Chi-square test, p<0.05).
|
15287194 |
2004 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results did not show any association between the MTHFR reductase C677T polymorphism and the increased risk of the development of end-stage renal disease.
|
12187113 |
2002 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These data indicated that Glu298Asp is the predisposing factor in ESRD, especially DM-derived ESRD.
|
12364359 |
2002 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, the frequent Glu298Asp polymorphism of ENOS is associated with a 5 year lower mean age at ESRD in this subset of ADPKD males.
|
11823442 |
2002 |